Economies of Scale in Cannabis - Moving from lab-scale CO2 Extraction (SFE) to production-scale

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Language: en

00:00:01.639
hello everyone and welcome to today's
00:00:04.039 00:00:04.049 live broadcast economies of scale in
00:00:07.280 00:00:07.290 cannabis moving from lab scale co2
00:00:10.450 00:00:10.460 supercritical fluid extraction to
00:00:13.490 00:00:13.500 production scale presented by the lit
00:00:16.570 00:00:16.580 tortilla the president and CEO of thark
00:00:20.179 00:00:20.189 energy I'm Suzy Valdez elaborate and
00:00:22.970 00:00:22.980 I'll be your moderator for today's event
00:00:24.970 00:00:24.980 we're delighted to bring you this
00:00:27.140 00:00:27.150 educational web seminar presented by lab
00:00:30.019 00:00:30.029 roots lab roots is the leading
00:00:31.970 00:00:31.980 scientific social networking website and
00:00:34.430 00:00:34.440 producer of educational virtual events
00:00:36.590 00:00:36.600 and webinars before we begin I want to
00:00:39.229 00:00:39.239 remind everyone that this event is
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00:01:14.750 00:01:14.760 presentation is educational and thus
00:01:16.880 00:01:16.890 offers continuing education credits
00:01:19.010 00:01:19.020 click on the continuing education
00:01:21.530 00:01:21.540 credits tab located on the top right
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00:01:25.789 00:01:25.799 follow the process to obtain those
00:01:27.950 00:01:27.960 credits please join me now in welcoming
00:01:30.130 00:01:30.140 dr. Georgia I will now turn the
00:01:32.810 00:01:32.820 presentation over to him welcome sir
00:01:38.020 00:01:38.030 good afternoon thank you for that
00:01:41.149 00:01:41.159 introduction I appreciate it and welcome
00:01:44.060 00:01:44.070 to all of you
00:01:44.929 00:01:44.939 this is lull in Saudia I'm the CEO of
00:01:47.660 00:01:47.670 thought process and today I want to talk
00:01:51.830 00:01:51.840 about supercritical fluid extraction in
00:01:55.670 00:01:55.680 particular but in general cannabis
00:01:57.770 00:01:57.780 extraction we'll start off with a
00:02:00.830 00:02:00.840 background on thought and course
00:02:02.840 00:02:02.850 experience in supercritical the
00:02:05.120 00:02:05.130 different extraction techniques that are
00:02:07.340 00:02:07.350 out there and we'll follow up with
00:02:09.760 00:02:09.770 issues related with scale and scale up
00:02:13.270 00:02:13.280 supercritical both on the extraction
00:02:16.030 00:02:16.040 side and also on the purification side
00:02:18.870 00:02:18.880 but those who do not know what's
00:02:22.290 00:02:22.300 supercritical is you'll see a slide on
00:02:25.270 00:02:25.280 the right-hand side and at the extreme
00:02:27.880 00:02:27.890 right you will see a point which says a
00:02:30.460 00:02:30.470 critical point as long as you operate
00:02:33.580 00:02:33.590 out the critical pressure and the
00:02:36.790 00:02:36.800 critical temperature you're in the
00:02:38.890 00:02:38.900 supercritical region that is what we are
00:02:41.800 00:02:41.810 working with here now if you look at the
00:02:44.080 00:02:44.090 horizontal line at the critical point as
00:02:47.140 00:02:47.150 long as you are above this point and
00:02:49.150 00:02:49.160 horizontally you can decrease the
00:02:52.180 00:02:52.190 pressure you can increase the
00:02:54.160 00:02:54.170 temperature you can play with all of
00:02:56.770 00:02:56.780 these parameters to get the right
00:02:59.050 00:02:59.060 extraction conditions you need or the
00:03:01.750 00:03:01.760 process you're trying to do now at the
00:03:05.770 00:03:05.780 very end I'll summarize with all the
00:03:08.140 00:03:08.150 lessons that we have learned today so to
00:03:11.530 00:03:11.540 give you back the history of
00:03:13.390 00:03:13.400 supercritical here in 1982 we started a
00:03:17.979 00:03:17.989 company called super X we were the first
00:03:21.240 00:03:21.250 supercritical company in the whole world
00:03:23.819 00:03:23.829 so you can see the background we have
00:03:26.259 00:03:26.269 been doing this for the last 35 years in
00:03:29.890 00:03:29.900 Super X we developed instrumentation
00:03:33.509 00:03:33.519 specifically focused on extraction and
00:03:36.430 00:03:36.440 chromatography we launched the first
00:03:39.130 00:03:39.140 capillary SFC in the world and
00:03:41.020 00:03:41.030 ultimately the company was sold to Isco
00:03:44.890 00:03:44.900 in 1990 I started far in 1990 in 1990 we
00:03:51.580 00:03:51.590 started working on various equipment for
00:03:54.430 00:03:54.440 supercritical but not the analytical
00:03:56.590 00:03:56.600 site we made pilot plant and production
00:03:59.500 00:03:59.510 scale onwards you know we went on to
00:04:03.190 00:04:03.200 spin out number of divisions from tar
00:04:05.560 00:04:05.570 and we started building large-scale
00:04:08.470 00:04:08.480 systems and we have built over 20
00:04:11.920 00:04:11.930 production scale I'm talking about 500
00:04:15.009 00:04:15.019 liter thousand liter systems in the last
00:04:17.860 00:04:17.870 ten years between 2007 and 2010 we have
00:04:26.670 00:04:26.680 done a number of different things we
00:04:28.890 00:04:28.900 built a prep scale SFC on words build
00:04:33.810 00:04:33.820 the largest act colonists have seen in
00:04:36.719 00:04:36.729 the world
00:04:37.260 00:04:37.270 we built a counter-current column going
00:04:39.659 00:04:39.669 up to 30 feet long where he can do
00:04:41.939 00:04:41.949 separations instead of using a
00:04:44.460 00:04:44.470 chromatographic separation we can use a
00:04:46.500 00:04:46.510 counter-current separation then in 2011
00:04:49.800 00:04:49.810 we built a large facility at the back of
00:04:52.350 00:04:52.360 our building that we are located today
00:04:54.629 00:04:54.639 it is a 25,000 GMP facility where we
00:04:58.379 00:04:58.389 extract astaxanthin which is a
00:05:02.689 00:05:02.699 antioxidant from algae called America
00:05:05.550 00:05:05.560 blue Wallis and late last year we
00:05:08.100 00:05:08.110 doubled that capacity so right now we
00:05:10.650 00:05:10.660 are one of the largest if not the
00:05:12.960 00:05:12.970 largest algae producing company in the
00:05:16.770 00:05:16.780 world over here algae extract essay
00:05:18.629 00:05:18.639 using supercritical fluids the
00:05:21.120 00:05:21.130 extraction pressure is fairly large
00:05:23.640 00:05:23.650 you're talking about 15,000 pounds of
00:05:26.640 00:05:26.650 pressure so it's one of the highest
00:05:28.879 00:05:28.889 extraction systems in the world onwards
00:05:32.040 00:05:32.050 we have moved into also making
00:05:34.700 00:05:34.710 chromatographic separation equipment
00:05:37.320 00:05:37.330 which is HPLC and SFC we do both
00:05:40.589 00:05:40.599 depending on the sample and we have
00:05:43.350 00:05:43.360 built a 600 mm which is a 24 an inch ID
00:05:46.830 00:05:46.840 column three of them for a
00:05:49.050 00:05:49.060 pharmaceutical company overseas so we
00:05:52.020 00:05:52.030 have a strong background in both
00:05:54.330 00:05:54.340 extraction and chromatographic
00:05:56.430 00:05:56.440 separations the mission of thought
00:06:00.659 00:06:00.669 process is to be a global leader in
00:06:02.760 00:06:02.770 supercritical fluid technology and
00:06:05.189 00:06:05.199 equipment by providing solutions
00:06:07.589 00:06:07.599 involving involving chemistry design
00:06:10.200 00:06:10.210 process development and optimization we
00:06:13.080 00:06:13.090 take our customers from concept through
00:06:15.020 00:06:15.030 commercialization our competitive
00:06:18.750 00:06:18.760 advantage in this critical area we are
00:06:22.409 00:06:22.419 the most experienced supercritical only
00:06:25.260 00:06:25.270 company we have been doing this for the
00:06:26.909 00:06:26.919 last 35 years we didn't start this a few
00:06:30.390 00:06:30.400 years ago when the medical marijuana
00:06:32.810 00:06:32.820 extraction market came into force
00:06:35.580 00:06:35.590 we have been doing supercritical long
00:06:38.279 00:06:38.289 before people on green tea
00:06:40.500 00:06:40.510 nology was fashionable from a design
00:06:44.160 00:06:44.170 point of view we bring all the different
00:06:46.290 00:06:46.300 process and equipment telic technologies
00:06:49.020 00:06:49.030 together we manufacture our own
00:06:51.090 00:06:51.100 equipment so we put things together
00:06:52.860 00:06:52.870 which is optimized solutions based on
00:06:57.150 00:06:57.160 the initial feasibility studies all the
00:06:59.790 00:06:59.800 way through production and all systems
00:07:03.210 00:07:03.220 as I mentioned earlier and major
00:07:04.860 00:07:04.870 components are designed developed and
00:07:06.600 00:07:06.610 assembled and one warranted by our
00:07:09.420 00:07:09.430 process and this is all done out of
00:07:11.610 00:07:11.620 Pittsburgh
00:07:12.450 00:07:12.460 Sylvania lastly we are customer centered
00:07:17.460 00:07:17.470 partnerships from proof of concept
00:07:19.320 00:07:19.330 through commercialization or their
00:07:21.810 00:07:21.820 production solution of choice so we are
00:07:24.420 00:07:24.430 very customer friendly company so the
00:07:27.900 00:07:27.910 examples of work that can be done with
00:07:29.970 00:07:29.980 supercritical is you can do polymer
00:07:32.190 00:07:32.200 purification you can remove solvents
00:07:34.290 00:07:34.300 from synthetic DNA astaxanthin from
00:07:36.810 00:07:36.820 algae you can do a less intense recovery
00:07:39.900 00:07:39.910 of residual specialty oils extraction of
00:07:42.720 00:07:42.730 spices flavors fragrance fragrances and
00:07:45.360 00:07:45.370 any active ingredient from herbs in
00:07:48.090 00:07:48.100 short if the wood oil is used we can
00:07:50.910 00:07:50.920 probably extracted from the natural
00:07:53.970 00:07:53.980 product besides extraction supercritical
00:07:56.760 00:07:56.770 can be used for reactions impregnation
00:07:59.850 00:07:59.860 scouting so there's a variety of
00:08:02.070 00:08:02.080 applications that you can use it for and
00:08:04.320 00:08:04.330 if you are trying to make specialty
00:08:06.600 00:08:06.610 products using these cannabinoids you
00:08:10.410 00:08:10.420 can use the impregnation technology to
00:08:13.290 00:08:13.300 do it for any kind of applications you
00:08:17.250 00:08:17.260 might have the what I'm going to start
00:08:22.860 00:08:22.870 off today is talk about different
00:08:25.020 00:08:25.030 extraction technologies there are really
00:08:29.190 00:08:29.200 five of them out there you can do with
00:08:32.040 00:08:32.050 ice water which is one of the oldest
00:08:34.200 00:08:34.210 techniques where you take your
00:08:37.130 00:08:37.140 cannabinoids you take your plant
00:08:39.600 00:08:39.610 material grind it up put it in ice water
00:08:41.760 00:08:41.770 and since THC and CBD and all the
00:08:45.030 00:08:45.040 cannabinoids are heavier they settle
00:08:47.250 00:08:47.260 down on the bottom it's a very simple
00:08:49.890 00:08:49.900 process but the overall extraction
00:08:51.960 00:08:51.970 efficiencies you can
00:08:54.330 00:08:54.340 use hydro cam solvents like propane
00:08:56.850 00:08:56.860 butane hexane these are all nonpolar
00:08:59.580 00:08:59.590 solvents very similar to supercritical
00:09:01.950 00:09:01.960 co2 but the disadvantage of these they
00:09:05.940 00:09:05.950 are highly explosive so you have to have
00:09:08.760 00:09:08.770 explosion proof requirements and there
00:09:11.430 00:09:11.440 are a lot of regulate ratios and how
00:09:13.740 00:09:13.750 much you can have these solvents at your
00:09:17.640 00:09:17.650 building and you know constraints
00:09:20.520 00:09:20.530 associated with that and that is a you
00:09:23.430 00:09:23.440 know always a worry of explosion so you
00:09:25.320 00:09:25.330 have to be a little careful about the
00:09:28.020 00:09:28.030 other technique which is the RSO which
00:09:30.390 00:09:30.400 is similar to the hydrocarbons but
00:09:32.220 00:09:32.230 instead of using propane butane and xane
00:09:34.350 00:09:34.360 you're using naphtha or isopropyl
00:09:36.360 00:09:36.370 alcohol the process is still very
00:09:38.340 00:09:38.350 similar the other extraction solvent
00:09:43.050 00:09:43.060 which is becoming popular these days is
00:09:45.120 00:09:45.130 ethanol ethanol is significantly more
00:09:47.550 00:09:47.560 polar than co2 so the kind of compounds
00:09:51.810 00:09:51.820 the selectivity is very different the
00:09:54.990 00:09:55.000 ethanol is a very good solvent because
00:09:57.210 00:09:57.220 it is physiologically compatible but
00:10:00.510 00:10:00.520 again from a regulatory point of view
00:10:02.280 00:10:02.290 there are restrictions on how much you
00:10:04.560 00:10:04.570 can use so if you're trying to scale
00:10:06.180 00:10:06.190 this it becomes a regulatory nightmare
00:10:10.200 00:10:10.210 to handle methanol on a scale the last
00:10:13.920 00:10:13.930 of course that we are talking about
00:10:15.810 00:10:15.820 today is supercritical co2 and we
00:10:18.480 00:10:18.490 believe supercritical co2 is great
00:10:21.270 00:10:21.280 solvent and the question is why and if
00:10:24.360 00:10:24.370 you look at the list here first we start
00:10:27.120 00:10:27.130 with it's a zero global warming
00:10:28.830 00:10:28.840 potential it's a zero ozone depletion
00:10:31.800 00:10:31.810 potential physiologically compatible
00:10:35.070 00:10:35.080 it's inexpensive and available
00:10:37.110 00:10:37.120 everywhere you're talking about one
00:10:39.570 00:10:39.580 hundred and fifty dollars a ton which is
00:10:42.300 00:10:42.310 really inexpensive and the most
00:10:45.090 00:10:45.100 important is he does not need any
00:10:47.190 00:10:47.200 explosion proof requirements so you can
00:10:49.890 00:10:49.900 almost put it up anywhere the other
00:10:52.770 00:10:52.780 advantage of supercritical is by varying
00:10:55.140 00:10:55.150 the temperature and pressure you can
00:10:58.320 00:10:58.330 extract different things and by running
00:11:02.070 00:11:02.080 a low temperature extraction you can get
00:11:04.650 00:11:04.660 high selectivity but the negative of
00:11:07.830 00:11:07.840 load
00:11:08.199 00:11:08.209 Reiter extraction is that you have a
00:11:10.299 00:11:10.309 high solvent to feed ratio so you have
00:11:12.699 00:11:12.709 to run the co2 that you are using for
00:11:16.329 00:11:16.339 now you know about a factor of 10 in the
00:11:19.840 00:11:19.850 same overall extraction efficiency on
00:11:23.230 00:11:23.240 the other hand you can increase the
00:11:24.939 00:11:24.949 temperature so you can do high
00:11:26.530 00:11:26.540 temperature and high pressure and you
00:11:28.720 00:11:28.730 get a very high efficiency of extraction
00:11:30.879 00:11:30.889 but the selectivity is low so you end up
00:11:33.999 00:11:34.009 extracting things like waxes which you
00:11:37.179 00:11:37.189 have to remove further and but overall
00:11:40.960 00:11:40.970 the solvent to fade ratio is low which
00:11:43.480 00:11:43.490 means you get high productivity so there
00:11:46.119 00:11:46.129 is advantages and disadvantages of any
00:11:49.509 00:11:49.519 of these things that you do you have to
00:11:51.730 00:11:51.740 look at the pros and cons decide what is
00:11:54.340 00:11:54.350 the right thing for you now in a typical
00:11:57.730 00:11:57.740 process you can see the schematic on the
00:11:59.980 00:11:59.990 left-hand side of the screen you have a
00:12:02.679 00:12:02.689 pump where you can pressurize the
00:12:05.519 00:12:05.529 vertical co2 and it goes you preheat it
00:12:09.519 00:12:09.529 then it goes into the extraction vessel
00:12:11.619 00:12:11.629 you extracted you depressurize it and
00:12:14.319 00:12:14.329 you collect it in a separator and the
00:12:16.509 00:12:16.519 co2 comes out and you recycle so the
00:12:19.299 00:12:19.309 major components here are pumps vessels
00:12:22.449 00:12:22.459 and separators these are the three major
00:12:24.850 00:12:24.860 components that govern the scale of
00:12:28.329 00:12:28.339 issues and you can get these vessels all
00:12:32.079 00:12:32.089 the way down from you know one liter
00:12:34.179 00:12:34.189 five liter to as much as 500 liters or
00:12:37.179 00:12:37.189 larger depending on who you go to now
00:12:42.100 00:12:42.110 when you come to sizing the important
00:12:44.769 00:12:44.779 question you have here is how do you
00:12:47.350 00:12:47.360 determine what size you need when you do
00:12:50.379 00:12:50.389 scale up the first and foremost question
00:12:53.049 00:12:53.059 that comes here is what is the solvent
00:12:54.999 00:12:55.009 to fade ratio you do that trials on a
00:12:58.929 00:12:58.939 lab scale 5 liter system and then
00:13:02.049 00:13:02.059 determine what's the solvent to feed
00:13:03.819 00:13:03.829 ratio the reason this is important is as
00:13:06.639 00:13:06.649 I mentioned earlier I'm preacher and
00:13:09.160 00:13:09.170 pressure play a major role in the
00:13:11.559 00:13:11.569 extraction so if you are doing low
00:13:13.329 00:13:13.339 temperatures you may need a solvent to
00:13:15.639 00:13:15.649 repay ratio of e 120 and if you do high
00:13:19.960 00:13:19.970 pressure and high temperature the
00:13:21.879 00:13:21.889 to feed ratios so solvent to feed ratio
00:13:25.929 00:13:25.939 controls your sizing so that's the first
00:13:28.599 00:13:28.609 thing you need to know once you know
00:13:30.939 00:13:30.949 solvent to feed ratio you define what is
00:13:33.759 00:13:33.769 the capacity you're going for is it in
00:13:36.879 00:13:36.889 kilos at a 100 kilos a day at Sun a day
00:13:39.970 00:13:39.980 what is the capacity and based on the
00:13:43.539 00:13:43.549 capacity and the solvent to feed ratio
00:13:45.849 00:13:45.859 they'll get you a number which is the
00:13:48.699 00:13:48.709 total amount of co2 that you need on a
00:13:51.039 00:13:51.049 daily basis and the next question
00:13:54.189 00:13:54.199 becomes once you have this number
00:13:56.710 00:13:56.720 whether you're doing this in a 8 hour
00:13:59.259 00:13:59.269 time frame or a 24 hour time frame you
00:14:02.109 00:14:02.119 can calculate the pump flow rate so we
00:14:05.079 00:14:05.089 start with the basic thing here pump
00:14:07.659 00:14:07.669 flow rate defines your capacity it does
00:14:11.049 00:14:11.059 not the vessel size which is what
00:14:13.210 00:14:13.220 everybody thinks it is actually the pump
00:14:16.449 00:14:16.459 flow rate if you have a small pump and
00:14:18.939 00:14:18.949 you put a little and if you even double
00:14:22.119 00:14:22.129 the size of the vessel it doesn't mean
00:14:24.579 00:14:24.589 that your capacity has gone up because
00:14:27.549 00:14:27.559 the capacity is controlled by what is
00:14:29.769 00:14:29.779 the flow rate of the pot so that is the
00:14:32.139 00:14:32.149 most critical thing from a scale a point
00:14:34.479 00:14:34.489 of view is defining the pump flow rate
00:14:36.909 00:14:36.919 which is a function of the solvent to
00:14:39.249 00:14:39.259 feed ratio and the capacity that you
00:14:41.590 00:14:41.600 need
00:14:42.539 00:14:42.549 once you define the pump flow rate then
00:14:45.519 00:14:45.529 you what you do is you design the vessel
00:14:48.009 00:14:48.019 diameter and the vessel diameter is
00:14:50.530 00:14:50.540 defined by the linear velocity of this
00:14:53.619 00:14:53.629 flow rate inside the vessel if you have
00:14:57.579 00:14:57.589 a very large vessel diameter and you
00:15:02.019 00:15:02.029 have a very low linear velocity and if
00:15:04.900 00:15:04.910 you have a very small vessel diameter
00:15:06.400 00:15:06.410 you have a very high linear velocity if
00:15:08.769 00:15:08.779 you have a run high linear velocity the
00:15:15.539 00:15:15.549 herbs or the plant material will go to
00:15:19.509 00:15:19.519 the other end of the vessel and get
00:15:21.249 00:15:21.259 stuck potentially plugging it so you
00:15:25.569 00:15:25.579 want to make sure you have an optimum
00:15:27.579 00:15:27.589 and there are numbers that we use over
00:15:30.400 00:15:30.410 here typically in the range of 20 feet
00:15:34.059 00:15:34.069 per second
00:15:35.160 00:15:35.170 so we use those to calculate what the
00:15:38.400 00:15:38.410 vessel diameter should be once we do the
00:15:41.910 00:15:41.920 vessel diameter we define the vessel
00:15:44.280 00:15:44.290 size by determining the vessel length
00:15:46.800 00:15:46.810 and that gives us the total diameter
00:15:49.250 00:15:49.260 total volume of the vessel between e
00:15:52.790 00:15:52.800 lastly this what I want to mention here
00:15:57.030 00:15:57.040 is the subcritical co2 extraction which
00:16:00.210 00:16:00.220 has high solvent afid ratios will force
00:16:04.139 00:16:04.149 you to use a vessel which has a very
00:16:06.630 00:16:06.640 large in diameter which obviously
00:16:09.060 00:16:09.070 increases the cost because of the
00:16:10.620 00:16:10.630 pressure while the supercritical
00:16:13.829 00:16:13.839 extraction which is high-pressure
00:16:15.329 00:16:15.339 high-temperature has much lower solvent
00:16:17.910 00:16:17.920 to feed ratios so you come up with
00:16:21.269 00:16:21.279 sizing for a large scale or on a scale
00:16:24.600 00:16:24.610 of issue now I can show you some vessel
00:16:28.110 00:16:28.120 equipment that are available in the
00:16:29.880 00:16:29.890 marketplace the one on the left that you
00:16:32.610 00:16:32.620 see typically a water's pro provides
00:16:35.160 00:16:35.170 five liter systems to ten liter systems
00:16:38.449 00:16:38.459 the one in the middle it's medium scale
00:16:41.759 00:16:41.769 you can get them from apex and one on
00:16:44.699 00:16:44.709 the right is a large scale system and
00:16:48.060 00:16:48.070 this is 750 liter to vessel system so
00:16:52.710 00:16:52.720 total of 1500 meters this one actually
00:16:55.500 00:16:55.510 operates at 15,000 pounds of pressure
00:16:58.350 00:16:58.360 that I talked to you earlier about and
00:17:00.120 00:17:00.130 we extract astaxanthin so this is our
00:17:03.150 00:17:03.160 system at our facility in Pittsburgh so
00:17:05.280 00:17:05.290 you can get variety of sizes and you
00:17:07.409 00:17:07.419 need to size them based on the previous
00:17:10.470 00:17:10.480 slide that I showed and come up with the
00:17:13.049 00:17:13.059 size that you need so again talking
00:17:17.309 00:17:17.319 about scale up issues over here how do
00:17:21.600 00:17:21.610 you calculate cost here's from our
00:17:23.909 00:17:23.919 experience we say capital cost is y
00:17:27.840 00:17:27.850 power X in other words if you had to
00:17:31.620 00:17:31.630 double the size so Y is a factor of two
00:17:35.130 00:17:35.140 and we power it to point six eight then
00:17:38.400 00:17:38.410 the capital cost will go up by one point
00:17:40.260 00:17:40.270 six so it's not linear it's not a
00:17:43.740 00:17:43.750 logarithmic the power is typically
00:17:48.930 00:17:48.940 powerup point six eight so every time
00:17:51.240 00:17:51.250 you double the size you can assume the
00:17:53.670 00:17:53.680 capital cost goes up by a factor of one
00:17:56.280 00:17:56.290 point six typically the utility cost is
00:18:03.210 00:18:03.220 a function of flow rate which largely
00:18:05.640 00:18:05.650 remains the same on a per pound basis
00:18:09.420 00:18:09.430 when you process it so you don't get
00:18:11.760 00:18:11.770 much reduction by going a scale up maybe
00:18:14.340 00:18:14.350 about three percent for every doubling
00:18:16.830 00:18:16.840 of the flow rate so you don't get a
00:18:18.300 00:18:18.310 substantial reduction on utility casting
00:18:21.990 00:18:22.000 and finally you come to labor the
00:18:25.590 00:18:25.600 unfortunate part of labor is labor
00:18:27.870 00:18:27.880 remains the same whether use you use a
00:18:31.050 00:18:31.060 five liter system or a hundred liter
00:18:33.660 00:18:33.670 system or a thousand liter system so
00:18:36.500 00:18:36.510 labor becomes the largest portion of
00:18:40.260 00:18:40.270 your cost and as you scale up labor
00:18:44.370 00:18:44.380 becomes a smaller portion of the overall
00:18:46.500 00:18:46.510 overall cost so it's very critical for
00:18:49.680 00:18:49.690 you if you want to drive the overall
00:18:52.500 00:18:52.510 cost down to scale up and scale up to as
00:18:55.560 00:18:55.570 large scale as possible the the other
00:19:05.700 00:19:05.710 way to design your system is to have
00:19:09.060 00:19:09.070 different configurations the basic
00:19:12.600 00:19:12.610 system is you have one vessel and one
00:19:15.540 00:19:15.550 pump and that simple straightforward you
00:19:18.510 00:19:18.520 have a vessel a pump and a separator you
00:19:21.300 00:19:21.310 are done that's what most people sell
00:19:23.700 00:19:23.710 you can go from here and say how do I
00:19:28.110 00:19:28.120 increase my Cassity you can have two
00:19:32.430 00:19:32.440 vessels and one pump and while the first
00:19:34.980 00:19:34.990 one is running you can load the second
00:19:38.460 00:19:38.470 vessel vessel get it ready and get it
00:19:41.160 00:19:41.170 moving and that will give you a 30%
00:19:43.950 00:19:43.960 increase in capacity that's a typical
00:19:46.920 00:19:46.930 number sometimes it's a little high
00:19:48.750 00:19:48.760 sometimes it's a little low it all
00:19:50.640 00:19:50.650 depends on what your total extraction
00:19:54.240 00:19:54.250 time is shorter the extraction time
00:19:57.140 00:19:57.150 greater effect it has longer the
00:19:59.820 00:19:59.830 extraction time less effect it has so
00:20:02.070 00:20:02.080 you can
00:20:02.580 00:20:02.590 who from a one vessel to a two vessel
00:20:04.680 00:20:04.690 system and all you are doing is adding a
00:20:07.019 00:20:07.029 cost of a vessel and couple valves and
00:20:09.480 00:20:09.490 that immediately increases your capacity
00:20:11.879 00:20:11.889 by about thirty percent the next thing
00:20:15.239 00:20:15.249 you can do is a see this configuration
00:20:16.999 00:20:17.009 this is very interesting so what do you
00:20:19.680 00:20:19.690 do what you have here is three vessels
00:20:22.200 00:20:22.210 and two of them are connected in series
00:20:26.340 00:20:26.350 and you have only one pump so the same
00:20:29.279 00:20:29.289 pump that you used in the first two
00:20:31.379 00:20:31.389 configurations you can use in the third
00:20:33.330 00:20:33.340 one and this co2 will go from the first
00:20:36.600 00:20:36.610 vessel to the second vessel and because
00:20:40.109 00:20:40.119 you have two vessels in series you have
00:20:42.570 00:20:42.580 the highest extraction efficiency in
00:20:46.409 00:20:46.419 other words if the first in the second
00:20:48.570 00:20:48.580 one gave you a 80% extraction efficiency
00:20:52.470 00:20:52.480 for the same conditions problem you'll
00:20:55.470 00:20:55.480 definitely get more than 80% it could be
00:20:58.139 00:20:58.149 85 it could be 90 it's a function of the
00:21:00.779 00:21:00.789 application but it's the highest you can
00:21:04.080 00:21:04.090 get and while the first two are running
00:21:07.799 00:21:07.809 the third one is being unloaded cleaned
00:21:10.680 00:21:10.690 and loaded back again so then then you
00:21:13.859 00:21:13.869 switch and you take the second one out
00:21:17.669 00:21:17.679 put the third one in front of the first
00:21:20.340 00:21:20.350 one and you continue the process and you
00:21:22.830 00:21:22.840 continue this every time so you will be
00:21:25.649 00:21:25.659 able to get the same 30% as the previous
00:21:29.669 00:21:29.679 one but your overall extraction
00:21:32.430 00:21:32.440 efficiency will be higher and you'll
00:21:34.440 00:21:34.450 come out with more material the material
00:21:37.470 00:21:37.480 that you're looking for that's important
00:21:39.749 00:21:39.759 and the other option here is you can
00:21:43.289 00:21:43.299 have three vessels and two pumps
00:21:48.720 00:21:48.730 actually and that will double the flow
00:21:50.820 00:21:50.830 rate or you can have one pump with 2x
00:21:52.830 00:21:52.840 the flow rate and you can get 2.6 X
00:21:56.220 00:21:56.230 which is the highest extraction
00:21:58.590 00:21:58.600 configuration from that point of view
00:22:00.470 00:22:00.480 the last one is you can do a parallel
00:22:03.029 00:22:03.039 configuration which is two vessels and
00:22:07.230 00:22:07.240 two pumps which is literally double of
00:22:09.450 00:22:09.460 the basic configuration that you see up
00:22:11.249 00:22:11.259 there and that will get you to X the
00:22:13.230 00:22:13.240 capacity but the only
00:22:15.190 00:22:15.200 doesn't give you is the highest
00:22:17.430 00:22:17.440 extraction efficiency which the serious
00:22:20.350 00:22:20.360 configuration kills so you can play with
00:22:23.200 00:22:23.210 these things depending on what your
00:22:27.039 00:22:27.049 needs are and come up with the right
00:22:28.899 00:22:28.909 configuration and the costing for each
00:22:31.419 00:22:31.429 one is obviously very different the
00:22:34.600 00:22:34.610 basic configuration and the parallel
00:22:36.340 00:22:36.350 configuration are literally twice 2x and
00:22:40.029 00:22:40.039 the capital cost will be 2x from that
00:22:43.330 00:22:43.340 point of view and the most expensive is
00:22:45.669 00:22:45.679 the three vessel one pump with two
00:22:47.710 00:22:47.720 Explorer eight that will be the most
00:22:49.509 00:22:49.519 expensive capital configuration but it
00:22:51.730 00:22:51.740 also has the highest capacity so we use
00:22:55.060 00:22:55.070 these different configurations to define
00:22:57.370 00:22:57.380 what our scale-up are and what our
00:22:59.830 00:22:59.840 configurations are to get to where we
00:23:03.279 00:23:03.289 want to get you now the practicality is
00:23:07.090 00:23:07.100 we believe that there's going to be
00:23:08.950 00:23:08.960 market consolidation so far we have had
00:23:12.879 00:23:12.889 a lot of people doing mom-and-pop
00:23:16.990 00:23:17.000 operations with small systems as the
00:23:20.409 00:23:20.419 market grows you will find that people
00:23:24.430 00:23:24.440 with scale are going to win because
00:23:27.810 00:23:27.820 labor is one of the largest portion of
00:23:31.060 00:23:31.070 the overall costing which when we talked
00:23:34.360 00:23:34.370 about in couple slides ago whether you
00:23:37.120 00:23:37.130 have a 5-liter system or a hundred meter
00:23:39.340 00:23:39.350 or a 500 liter system you need the same
00:23:41.860 00:23:41.870 amount of labor so if you want to drive
00:23:44.470 00:23:44.480 the overall costing down you reduce
00:23:48.009 00:23:48.019 labor as a percentage and the only way
00:23:50.710 00:23:50.720 to do that is by going scale now this
00:23:55.840 00:23:55.850 has been shown to be true for other
00:23:58.379 00:23:58.389 nutraceuticals and here are just three
00:24:00.789 00:24:00.799 examples whether it's fish oil or Co Q
00:24:02.799 00:24:02.809 10 or astaxanthin in all of these things
00:24:06.009 00:24:06.019 scale wins and people end up moving from
00:24:09.580 00:24:09.590 small-scale systems to large-scale
00:24:11.139 00:24:11.149 systems and we expect this to be the
00:24:16.149 00:24:16.159 same even for the canvas industry now
00:24:20.110 00:24:20.120 the question becomes the next question
00:24:22.509 00:24:22.519 becomes is when you get to scale are we
00:24:25.419 00:24:25.429 better off contracting or be better of
00:24:28.299 00:24:28.309 doing
00:24:28.720 00:24:28.730 tassels that's a function of scale like
00:24:34.180 00:24:34.190 in so the question if I do have to
00:24:36.640 00:24:36.650 repeat the question should everyone whom
00:24:38.770 00:24:38.780 they're SFE or will be less expensive to
00:24:41.650 00:24:41.660 send it out to LA scale processors now
00:24:44.560 00:24:44.570 in the whole food industry especially in
00:24:48.520 00:24:48.530 the cannabis right now we do not have
00:24:51.280 00:24:51.290 major regulations because cannabis is
00:24:55.810 00:24:55.820 not looked well upon by the FDA but as
00:24:58.360 00:24:58.370 soon as the regulations change you can
00:25:01.240 00:25:01.250 expect significant regulations coming
00:25:03.640 00:25:03.650 down to follow cGMP requirements for the
00:25:07.240 00:25:07.250 extraction and once you say you have
00:25:10.090 00:25:10.100 cgmp requirements for your product you
00:25:12.669 00:25:12.679 have a ton of quality control procedures
00:25:16.240 00:25:16.250 that you need to fall typically you may
00:25:20.470 00:25:20.480 have three to five people dedicated to
00:25:23.110 00:25:23.120 follow this cGMP requirements and as a
00:25:27.370 00:25:27.380 percentage if you have a small
00:25:29.500 00:25:29.510 operations they become very very
00:25:31.810 00:25:31.820 expensive
00:25:32.710 00:25:32.720 it also requires you to have in-house
00:25:36.039 00:25:36.049 expertise or all the different things
00:25:38.799 00:25:38.809 whether you need a mechanical engineer
00:25:40.960 00:25:40.970 to maintain the equipment a chemical
00:25:43.180 00:25:43.190 engineer to run the process or quality
00:25:47.710 00:25:47.720 control people analytical people and
00:25:50.470 00:25:50.480 especially if you want to anything that
00:25:53.350 00:25:53.360 says we need certification we need cGMP
00:25:56.980 00:25:56.990 certification we need kosher
00:25:58.900 00:25:58.910 certification halal certification
00:26:00.490 00:26:00.500 organic certification all of this
00:26:03.130 00:26:03.140 requires significant amount of paperwork
00:26:05.620 00:26:05.630 which drives the Casta should say kosta
00:26:11.740 00:26:11.750 so what are our options our options are
00:26:14.440 00:26:14.450 threefold right so you can have a co-op
00:26:17.740 00:26:17.750 style for ethanol exchange the
00:26:20.680 00:26:20.690 extractions of corn oil and canola oil
00:26:22.600 00:26:22.610 you can see a number of farmers join
00:26:25.419 00:26:25.429 together and they built their facility
00:26:27.730 00:26:27.740 and that facility ran that on to extract
00:26:31.120 00:26:31.130 the oil or canola to the oil you can do
00:26:33.700 00:26:33.710 the same thing and we expect some of
00:26:35.409 00:26:35.419 these to happen in the industry the
00:26:37.960 00:26:37.970 other thing we also see is people will
00:26:40.810 00:26:40.820 bring in
00:26:41.620 00:26:41.630 while units will bring them to your
00:26:43.810 00:26:43.820 facility and they will run it and they
00:26:46.840 00:26:46.850 will run it because they have all the
00:26:48.850 00:26:48.860 expertise which comes along with the
00:26:51.400 00:26:51.410 mobile units so they'll run it produce
00:26:53.650 00:26:53.660 the oil the oil that you want whether
00:26:55.810 00:26:55.820 it's winter ice oil or refined oil or
00:26:58.450 00:26:58.460 even the unrefined oil any of those
00:27:03.730 00:27:03.740 things they can provide that for you so
00:27:06.520 00:27:06.530 you will have places where people will
00:27:08.920 00:27:08.930 drive in and attract one or two trailer
00:27:11.350 00:27:11.360 trucks and provide these mobile units to
00:27:13.840 00:27:13.850 process at your site and of course the
00:27:16.630 00:27:16.640 last one is you'll find people who are
00:27:18.970 00:27:18.980 set up large-scale contract
00:27:20.820 00:27:20.830 processing facility where you can send
00:27:23.590 00:27:23.600 the material to them and they will
00:27:24.910 00:27:24.920 process it and send it back to you and
00:27:26.680 00:27:26.690 they have all the quality control people
00:27:30.730 00:27:30.740 the engineers everything to manage it so
00:27:33.310 00:27:33.320 it on a per kg basis it could
00:27:35.950 00:27:35.960 potentially drive the cost down so those
00:27:38.980 00:27:38.990 are the three options that you have
00:27:40.870 00:27:40.880 besides you building it yourself and
00:27:43.780 00:27:43.790 maintaining it now when you go from
00:27:47.530 00:27:47.540 extraction to purification it's the
00:27:51.610 00:27:51.620 knowledge is even more critical than
00:27:53.680 00:27:53.690 extraction chromatographic separations
00:27:56.320 00:27:56.330 require a greater technical knowledge
00:27:58.920 00:27:58.930 but the scale of issues are similar to
00:28:02.020 00:28:02.030 extraction the regulatory issues are
00:28:04.510 00:28:04.520 similar and so we have little ease the
00:28:09.340 00:28:09.350 same scale of issues that we talked
00:28:12.160 00:28:12.170 about for the extraction site what you
00:28:15.340 00:28:15.350 see on the slide here is a prep scale
00:28:19.330 00:28:19.340 system with three separators for a Croma
00:28:22.330 00:28:22.340 drain a supercritical fluid
00:28:23.220 00:28:23.230 chromatographic system and what you see
00:28:26.020 00:28:26.030 on the right is the largest tack column
00:28:28.870 00:28:28.880 for supercritical fluids built by car
00:28:30.880 00:28:30.890 and it's in Malaysia they use it to
00:28:33.610 00:28:33.620 separate the oils from palm oil so if
00:28:39.340 00:28:39.350 you want if you're looking to do
00:28:41.080 00:28:41.090 multiple kilograms per day then the
00:28:44.320 00:28:44.330 first question that comes is you need a
00:28:47.340 00:28:47.350 large diameter column and these columns
00:28:51.160 00:28:51.170 are available all the way from a
00:28:54.080 00:28:54.090 just to 24 inches and the pressure
00:28:56.630 00:28:56.640 ratings on these columns have to be in
00:28:58.730 00:28:58.740 the range of 175 to 300 bar and the flow
00:29:02.299 00:29:02.309 rates of co2 and who solvent typically
00:29:05.570 00:29:05.580 in this case is ethanol range as little
00:29:08.000 00:29:08.010 as 5 kilos and memory to as much as 15
00:29:10.760 00:29:10.770 kilos so those are the typical
00:29:13.269 00:29:13.279 specifications for a multiple kilograms
00:29:16.340 00:29:16.350 per day of chromatographic product and
00:29:20.919 00:29:20.929 then the scale scalar parameters are
00:29:24.169 00:29:24.179 very straightforward if you double the
00:29:26.960 00:29:26.970 diameter of column the total amount that
00:29:31.460 00:29:31.470 you can process is typically 4 times and
00:29:34.580 00:29:34.590 the productivity is directly
00:29:36.470 00:29:36.480 proportional to flow rate selectivity
00:29:39.289 00:29:39.299 which is very critical for
00:29:40.789 00:29:40.799 chromatographic it's a function of
00:29:42.830 00:29:42.840 particle size smaller the particles you
00:29:45.560 00:29:45.570 get a greater selectivity but the cost
00:29:47.720 00:29:47.730 of the particles the chromatographic
00:29:51.649 00:29:51.659 particles go up so you need to do an
00:29:54.889 00:29:54.899 optimization typically we suggest
00:29:57.860 00:29:57.870 something in the 10 to 15 micron range
00:30:00.950 00:30:00.960 our probably the ideal particle size
00:30:03.799 00:30:03.809 from a cost performance basis our speed
00:30:07.399 00:30:07.409 capacity and selectivity are very
00:30:11.210 00:30:11.220 closely interrelated in chromatographic
00:30:13.669 00:30:13.679 systems you can get high-speed high
00:30:16.370 00:30:16.380 capacity and high selectivity if we want
00:30:19.159 00:30:19.169 all three of them then it the cost
00:30:22.000 00:30:22.010 quadruples so you have to optimize this
00:30:25.010 00:30:25.020 to get these solutions that you're
00:30:27.440 00:30:27.450 looking for lastly I have couple slides
00:30:32.419 00:30:32.429 here which I'd like to conclude my talk
00:30:36.049 00:30:36.059 and talk about what lessons we have
00:30:39.889 00:30:39.899 learned today
00:30:40.899 00:30:40.909 the first one is sizing is a function of
00:30:44.389 00:30:44.399 solvent to feed ratio the capacity of
00:30:48.139 00:30:48.149 the pump the capacity of the system that
00:30:50.840 00:30:50.850 you want we are looking for the pump
00:30:52.850 00:30:52.860 flow rate the vessel linear velocity and
00:30:55.820 00:30:55.830 all of that so those are all
00:30:58.039 00:30:58.049 interrelated and you start with the
00:31:00.470 00:31:00.480 solvent to feed ratio as a tea you get
00:31:03.080 00:31:03.090 the rest of the kilometres subcritical
00:31:07.070 00:31:07.080 extraction is very selective it's a
00:31:10.580 00:31:10.590 great way to do it but it has a very
00:31:12.830 00:31:12.840 high solvent to fade ratio and a lower
00:31:16.340 00:31:16.350 efficiency so you have to pencil what
00:31:21.860 00:31:21.870 kind of product you're looking for and
00:31:24.560 00:31:24.570 if you're looking for winterized oil
00:31:28.450 00:31:28.460 critical extraction is a good way to go
00:31:31.130 00:31:31.140 without going through a thermal
00:31:32.690 00:31:32.700 extraction and the packet the
00:31:36.590 00:31:36.600 supercritical extraction has a much
00:31:39.139 00:31:39.149 lower solvent to failure ratio typically
00:31:41.480 00:31:41.490 a factor of 5 to 10 less than the
00:31:43.879 00:31:43.889 subcritical extraction it gives you a
00:31:46.460 00:31:46.470 higher extraction efficiencies because
00:31:49.129 00:31:49.139 you're running at higher temperatures
00:31:50.750 00:31:50.760 and pressure but it extracts waxes and
00:31:53.240 00:31:53.250 other unwanted products so what you have
00:31:55.610 00:31:55.620 to do is once you extract this you have
00:31:57.769 00:31:57.779 to go to a conventional winterization
00:31:59.690 00:31:59.700 using ethanol and that cost time and
00:32:02.899 00:32:02.909 money so your it's a trade-off whether
00:32:05.870 00:32:05.880 you want subcritical or supercritical
00:32:07.330 00:32:07.340 extraction sometimes a good solution
00:32:12.200 00:32:12.210 might work you may want to do a
00:32:14.149 00:32:14.159 subcritical extraction to get a clean
00:32:18.220 00:32:18.230 winterized oil and then go back and
00:32:20.840 00:32:20.850 change change the pressure to a higher
00:32:22.820 00:32:22.830 pressure and higher temperature go back
00:32:25.190 00:32:25.200 and extract what's left to work so you
00:32:27.379 00:32:27.389 overall you get higher efficiency and
00:32:30.049 00:32:30.059 you get two products one is a winterized
00:32:33.110 00:32:33.120 oil directly the other one is where you
00:32:36.320 00:32:36.330 have to do anything it's an all
00:32:38.060 00:32:38.070 extraction and produce of interest oil
00:32:39.830 00:32:39.840 and quite a few people will take both
00:32:42.320 00:32:42.330 these oils and mix them together to get
00:32:44.659 00:32:44.669 a complete spectacle spectrum oil so
00:32:48.590 00:32:48.600 those are the things in this V I'm going
00:32:53.720 00:32:53.730 to summarize by saying we do expect
00:32:56.419 00:32:56.429 consolidation to happen we expect as the
00:33:00.799 00:33:00.809 market grows you have larger and larger
00:33:03.320 00:33:03.330 people coming in to play both internal
00:33:06.830 00:33:06.840 for their own needs and also external
00:33:09.860 00:33:09.870 for working with other people so
00:33:13.549 00:33:13.559 large-scale extraction will be the norm
00:33:15.500 00:33:15.510 as we go in the future many group will
00:33:18.680 00:33:18.690 either set up their
00:33:21.470 00:33:21.480 wherever they think they have the
00:33:23.670 00:33:23.680 technical capability and the money to do
00:33:26.549 00:33:26.559 it so they don't have to send the
00:33:27.870 00:33:27.880 material but that does not work for
00:33:30.540 00:33:30.550 everybody
00:33:32.090 00:33:32.100 they'll have mobile extraction units
00:33:34.740 00:33:34.750 which will come to your facility to do
00:33:37.110 00:33:37.120 this high-technology extraction as a
00:33:39.299 00:33:39.309 service at your site or you can go to a
00:33:43.920 00:33:43.930 toll processor who will provide you the
00:33:46.140 00:33:46.150 same service at their facility so you
00:33:48.840 00:33:48.850 have all of these options and you can
00:33:51.720 00:33:51.730 expect every one of them to be in be a
00:33:58.590 00:33:58.600 solution for what you are trying to do
00:34:00.270 00:34:00.280 and depending on what you would like to
00:34:03.360 00:34:03.370 get at the end of it you can pick one or
00:34:05.880 00:34:05.890 the other of course if you can if you
00:34:09.210 00:34:09.220 have the money the best is to set up
00:34:11.760 00:34:11.770 your own large-scale extraction unit
00:34:13.530 00:34:13.540 because you can control everything you
00:34:16.200 00:34:16.210 can control what you are trying to
00:34:18.419 00:34:18.429 extract the technology and it's all
00:34:21.720 00:34:21.730 internal but that might not worker
00:34:24.389 00:34:24.399 forever for everybody in that case you
00:34:27.090 00:34:27.100 might be better off going to an outside
00:34:29.250 00:34:29.260 facility or the last one is as I
00:34:33.810 00:34:33.820 mentioned earlier a group of people can
00:34:36.000 00:34:36.010 join together create a co-op and run the
00:34:39.030 00:34:39.040 coop for all their shareholders so all
00:34:42.480 00:34:42.490 these options are available and with
00:34:45.300 00:34:45.310 that I would like to conclude and say
00:34:48.780 00:34:48.790 our process will be happy to be an
00:34:51.990 00:34:52.000 extraction and purification partner and
00:34:54.240 00:34:54.250 if you have any questions please feel
00:34:57.390 00:34:57.400 free to let me know and I'll be happy to
00:35:00.300 00:35:00.310 answer I do very much for listening to
00:35:03.420 00:35:03.430 me today thank you dr. tortilla for that
00:35:09.600 00:35:09.610 informative presentation we will now
00:35:11.490 00:35:11.500 start the live Q&A portion of this
00:35:14.160 00:35:14.170 webinar if you have any questions you'd
00:35:16.140 00:35:16.150 like to ask please do so now just click
00:35:18.300 00:35:18.310 on that ask a question drop down box
00:35:20.700 00:35:20.710 located on the far left of your
00:35:23.070 00:35:23.080 presentation window type the question
00:35:25.350 00:35:25.360 into the box that appears on the screen
00:35:26.940 00:35:26.950 and click the send button will answer as
00:35:29.580 00:35:29.590 many questions as we have time for so
00:35:32.460 00:35:32.470 let's take a look
00:35:33.450 00:35:33.460 our incoming questions from our audience
00:35:35.430 00:35:35.440 our first question doctor Sharia is at
00:35:39.150 00:35:39.160 what point is it better to subcontract
00:35:42.359 00:35:42.369 instead of purchasing the extraction so
00:35:47.550 00:35:47.560 I would say it's really a trade-off
00:35:49.200 00:35:49.210 between capital investment and
00:35:51.210 00:35:51.220 subcontract costing setting up a
00:35:54.180 00:35:54.190 facility especially a large one requires
00:35:57.240 00:35:57.250 a lot of handling and people all of
00:36:00.990 00:36:01.000 these cost money and time it's always
00:36:04.020 00:36:04.030 cheaper especially in the short term to
00:36:06.780 00:36:06.790 subcontract the extraction and the
00:36:08.550 00:36:08.560 purification this gives you the ability
00:36:11.550 00:36:11.560 to go to different vendors and when your
00:36:15.329 00:36:15.339 volume gets very large then you can
00:36:18.030 00:36:18.040 think about setting up your own facility
00:36:20.089 00:36:20.099 because by this time you have learned
00:36:23.310 00:36:23.320 the business you're making money and you
00:36:25.890 00:36:25.900 have the time and money to invest in
00:36:27.510 00:36:27.520 your own facility optimizing to the
00:36:30.599 00:36:30.609 products that you want thank you doctor
00:36:36.930 00:36:36.940 Sharia and this next question from an
00:36:38.970 00:36:38.980 audience member is two-part question is
00:36:41.720 00:36:41.730 supercritical co2 extraction process too
00:36:45.930 00:36:45.940 complicated and do I need highly
00:36:48.750 00:36:48.760 technical people to handle that yes or
00:36:52.560 00:36:52.570 no the process is fairly simple but
00:36:56.220 00:36:56.230 because it is high pressure it requires
00:36:59.640 00:36:59.650 the use of properly designed products
00:37:02.130 00:37:02.140 and caution when you using them in other
00:37:05.460 00:37:05.470 words if you have nuts and bolts
00:37:07.370 00:37:07.380 tightening you have to tighten them so
00:37:10.230 00:37:10.240 you really have to take care to do this
00:37:12.570 00:37:12.580 properly you cannot be them circle about
00:37:15.270 00:37:15.280 it you can also think of the process
00:37:18.750 00:37:18.760 based on the raw material and that
00:37:21.599 00:37:21.609 requires a technical understanding of
00:37:24.390 00:37:24.400 what you are trying to do so is it
00:37:27.450 00:37:27.460 complicated yes it's a little bit
00:37:29.400 00:37:29.410 complicated but if you have the right
00:37:32.370 00:37:32.380 people you can handle it
00:37:35.750 00:37:35.760 thank you and I want to remind our
00:37:38.339 00:37:38.349 audience members that any questions not
00:37:40.589 00:37:40.599 answered today will be answered via
00:37:42.720 00:37:42.730 email our next question is
00:37:46.340 00:37:46.350 is there any use for the left over Rafa
00:37:50.450 00:37:50.460 to raffinate I think that's a very good
00:37:53.810 00:37:53.820 question that is many ways to figure
00:37:59.240 00:37:59.250 this out the simplest one is you dispose
00:38:01.970 00:38:01.980 it off or you burn it and you can take
00:38:06.260 00:38:06.270 the heat that generator to produce hot
00:38:08.180 00:38:08.190 water or electricity
00:38:09.830 00:38:09.840 so that's thermal energy that you can
00:38:11.960 00:38:11.970 get from your raw material but the more
00:38:15.380 00:38:15.390 interesting thing is because the
00:38:18.080 00:38:18.090 cannabis plant is a high fibrous plant
00:38:20.990 00:38:21.000 and it's been used for years - in
00:38:24.410 00:38:24.420 textiles and ropes it becomes a great
00:38:27.680 00:38:27.690 substitute or paper or text in textiles
00:38:32.180 00:38:32.190 so you can find these upcoming new
00:38:37.370 00:38:37.380 applications for the leftover material
00:38:39.640 00:38:39.650 which if you had to set up a plan to do
00:38:42.950 00:38:42.960 it it just makes good economic sense and
00:38:46.370 00:38:46.380 it gets a faster return of investment
00:38:51.160 00:38:51.170 thank you for that before we close dr.
00:38:53.780 00:38:53.790 Sharia do you want to provide the
00:38:55.010 00:38:55.020 audience with any closing remarks I I
00:38:59.090 00:38:59.100 just want to say that supercritical co2
00:39:01.700 00:39:01.710 is a great shoe you know as I mentioned
00:39:06.230 00:39:06.240 earlier you cannot get a better solvent
00:39:09.140 00:39:09.150 it's physiologically compatible it's
00:39:11.750 00:39:11.760 inexpensive if you know how to handle it
00:39:14.810 00:39:14.820 you should use it you can use it
00:39:18.340 00:39:18.350 efficiently it can be very selective it
00:39:22.640 00:39:22.650 just makes the whole process go easy and
00:39:25.490 00:39:25.500 you're not polluting the environment
00:39:28.690 00:39:28.700 thank you again dr. Shar dia for your
00:39:30.920 00:39:30.930 presentation and your important research
00:39:32.510 00:39:32.520 I'd also like to thank lab roots for
00:39:35.270 00:39:35.280 making today's educational webcast
00:39:37.130 00:39:37.140 possible before I go I want to remind
00:39:39.440 00:39:39.450 everyone that today's webcast will be
00:39:41.480 00:39:41.490 available for on-demand viewing through
00:39:43.850 00:39:43.860 June 2018 you'll get an email from
00:39:47.360 00:39:47.370 laborat the swipe cast will be available
00:39:50.390 00:39:50.400 for replay please share that
00:39:52.310 00:39:52.320 announcement with your colleagues who
00:39:53.630 00:39:53.640 may have missed today's live event
00:39:55.100 00:39:55.110 that's all for now and thanks for
00:39:57.050 00:39:57.060 joining us we hope
00:39:58.080 00:39:58.090 see you again soon bye-bye thank you all
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